InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL16

Summary

InnateDB Gene

IDBG-19403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL16

Gene Name

chemokine (C-X-C motif) ligand 16

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000161921

Encoded Proteins

IDBP-19407

chemokine (C-X-C motif) ligand 16

IDBP-757688

IDBP-758671

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20874518

[Mus musculus] Cxcl16 is a chemoattractant in cerebrospinal fluid in early pneumococcal meningitis where Cxcl16 was found to be upregulated in RAW264.7 macrophages (but not in neutrophils and endothelial cells) upon pneumococcal stimulation. Cxcl16 upregulation in vivo was dependent on Toll-like receptor (TLR) 2/TLR4 and MyD88 signaling.

PMID 25456160

[Mus musculus] Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:4733526-4739922

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000293778	ENSP00000293778
ENST00000576153
ENST00000573123	ENSP00000460145
ENST00000574412	ENSP00000459592
ENST00000575168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005102	receptor binding
GO:0008009	chemokine activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0034097	response to cytokine
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0048247	lymphocyte chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000018920

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

I3L333

UniProt Splice Variant

Entrez Gene

58191

UniGene

Hs.513885 Hs.737318

RefSeq

NM_001100812 NM_022059

HUGO

HGNC:16642

OMIM

605398

CCDS

CCDS11052

HPRD

16103

IMGT

EMBL

AC091153

GenPept

RNA Seq Atlas

58191