Homo sapiens Gene: CXCL16
Summary
InnateDB Gene IDBG-19403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL16
Gene Name chemokine (C-X-C motif) ligand 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161921
Encoded Proteins
chemokine (C-X-C motif) ligand 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cxcl16 is a chemoattractant in cerebrospinal fluid in early pneumococcal meningitis where Cxcl16 was found to be upregulated in RAW264.7 macrophages (but not in neutrophils and endothelial cells) upon pneumococcal stimulation. Cxcl16 upregulation in vivo was dependent on Toll-like receptor (TLR) 2/TLR4 and MyD88 signaling.
[Mus musculus] Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4733526-4739922
Strand Reverse strand
Band p13.2
Transcripts
ENST00000293778 ENSP00000293778
ENST00000576153
ENST00000573123 ENSP00000460145
ENST00000574412 ENSP00000459592
ENST00000575168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005044 scavenger receptor activity
GO:0005102 receptor binding
GO:0008009 chemokine activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0034097 response to cytokine
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
GO:0048247 lymphocyte chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H2A7
TrEMBL I3L333
UniProt Splice Variant
Entrez Gene 58191
UniGene Hs.513885 Hs.737318
RefSeq NM_022059 NM_001100812
HUGO HGNC:16642
OMIM 605398
CCDS CCDS11052
HPRD 16103
IMGT
EMBL AC091153 AF275260 AF301016 AF337812 AK027389 AK292114 AK315017 AY358909 BC017588 BC044930 EF064742
GenPept AAG31750 AAG34365 AAH17588 AAH44930 AAK38275 AAQ89268 ABK41925 BAB55078 BAF84803 BAG37507
RNA Seq Atlas 58191