InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rpa2

Summary

InnateDB Gene

IDBG-194340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpa2

Gene Name

replication protein A2

Synonyms

AA409079; AI325195; AU020965; Rf-A2; RPA34

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028884

Encoded Proteins

IDBP-194342

replication protein A2

IDBP-539236

replication protein A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117748:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:132768332-132778752

Strand

Forward strand

Band

D2.3

Transcripts

ENSMUST00000102561	ENSMUSP00000099621
ENSMUST00000153046
ENSMUST00000130090
ENSMUST00000133415
ENSMUST00000130444
ENSMUST00000156968	ENSMUSP00000123780

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	82 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0031625	ubiquitin protein ligase binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006298	mismatch repair
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0031571	mitotic G1 DNA damage checkpoint
GO:2000001	regulation of DNA damage checkpoint

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005662	DNA replication factor A complex
GO:0016605	PML body
GO:0035861	site of double-strand break

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117748

View Gene Order

ENSBTAG00000006225

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03030

DNA replication pathway

mmu03420

Nucleotide excision repair pathway

mmu03440

Homologous recombination pathway

mmu03430

Mismatch repair pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_6769

Activation of ATR in response to replication stress pathway

REACT_7999

Removal of the Flap Intermediate from the C-strand pathway

REACT_8027

Processive synthesis on the C-strand of the telomere pathway

REACT_7961

Telomere C-strand (Lagging Strand) Synthesis pathway

REACT_70

Removal of the Flap Intermediate pathway

REACT_1385

Processive synthesis on the lagging strand pathway

REACT_1095

Activation of the pre-replicative complex pathway

REACT_1993

Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway

REACT_74

Gap-filling DNA repair synthesis and ligation in TC-NER pathway

REACT_1628

Transcription-coupled NER (TC-NER) pathway

REACT_311

Dual incision reaction in GG-NER pathway

REACT_257

Formation of incision complex in GG-NER pathway

REACT_378

Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway

REACT_1998

Gap-filling DNA repair synthesis and ligation in GG-NER pathway

REACT_2055

Processing of DNA double-strand break ends pathway

REACT_2141

Assembly of the RAD51-ssDNA nucleoprotein complex pathway

REACT_408

Presynaptic phase of homologous DNA pairing and strand exchange pathway

REACT_1763

Homologous DNA pairing and strand exchange pathway

REACT_27271

Meiotic recombination pathway

REACT_383

DNA Replication pathway

REACT_120956

Cellular responses to stress pathway

REACT_2014

Synthesis of DNA pathway

REACT_200780

Regulation of HSF1-mediated heat shock response pathway

REACT_1874

Homologous Recombination Repair pathway

REACT_21267

Mitotic G1-G1/S phases pathway

REACT_899

S Phase pathway

REACT_22172

Chromosome Maintenance pathway

REACT_828

G2/M Checkpoints pathway

REACT_734

DNA Replication Pre-Initiation pathway

REACT_2253

Global Genomic NER (GG-NER) pathway

REACT_7970

Telomere Maintenance pathway

REACT_1783

G1/S Transition pathway

REACT_2054

Double-Strand Break Repair pathway

REACT_115566

Cell Cycle pathway

REACT_228145

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway

REACT_200819

Cellular response to heat stress pathway

REACT_1725

M/G1 Transition pathway

REACT_1587

Homologous recombination repair of replication-independent double-strand breaks pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_932

DNA strand elongation pathway

REACT_228019

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_228013

Mismatch Repair pathway

REACT_111183

Meiosis pathway

REACT_200744

HSF1 activation pathway

REACT_8030

Extension of Telomeres pathway

REACT_312

Lagging Strand Synthesis pathway

REACT_1826

Nucleotide Excision Repair pathway

REACT_216

DNA Repair pathway

REACT_1538

Cell Cycle Checkpoints pathway

KEGG

hsa03030

DNA replication pathway

hsa03420

Nucleotide excision repair pathway

hsa03440

Homologous recombination pathway

hsa03430

Mismatch repair pathway

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

atr_pathway

ATR signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2870 Mm.460140

RefSeq

NM_011284

OMIM

CCDS

CCDS18734

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas