Version 5.4
Mus musculus Gene: Tnni1
Summary
InnateDB Gene IDBG-195053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnni1
Gene Name troponin I, skeletal, slow 1
Synonyms 2700018B22Rik; AI747285; ssTnI
Species Mus musculus
Ensembl Gene ENSMUSG00000026418
Encoded Proteins
IDBP-541481
troponin I, skeletal, slow 1
IDBP-533547
troponin I, skeletal, slow 1
IDBP-541479
troponin I, skeletal, slow 1
IDBP-532299
troponin I, skeletal, slow 1
IDBP-538771
troponin I, skeletal, slow 1
IDBP-537767
troponin I, skeletal, slow 1
IDBP-540208
troponin I, skeletal, slow 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159173:
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:135779434-135810989
Strand Forward strand
Band E4
Transcripts
ENSMUST00000132795 ENSMUSP00000121122
ENSMUST00000152208 ENSMUSP00000121966
ENSMUST00000152075 ENSMUSP00000121343
ENSMUST00000137331
ENSMUST00000154463 ENSMUSP00000122925
ENSMUST00000139986 ENSMUSP00000123049
ENSMUST00000148201 ENSMUSP00000123509
ENSMUST00000129217 ENSMUSP00000119848
ENSMUST00000187830
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0046872 metal ion binding
Biological Process
GO:0055010 ventricular cardiac muscle tissue morphogenesis
Cellular Component
GO:0005861 troponin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159173
View Gene Order
ENSBTAG00000047231
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.44379
RefSeq NM_001112702 NM_021467
OMIM
CCDS CCDS48374
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca