Version 5.4
Mus musculus Gene: Tnnt2
Summary
InnateDB Gene IDBG-195088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnnt2
Gene Name troponin T2, cardiac
Synonyms cTnT; Tnt
Species Mus musculus
Ensembl Gene ENSMUSG00000026414
Encoded Proteins
IDBP-195090
troponin T2, cardiac
IDBP-256741
troponin T2, cardiac
IDBP-256743
troponin T2, cardiac
IDBP-256745
troponin T2, cardiac
IDBP-713745
IDBP-713760
IDBP-714026
IDBP-788204
troponin T2, cardiac
IDBP-788207
troponin T2, cardiac
IDBP-788208
troponin T2, cardiac
IDBP-788209
troponin T2, cardiac
IDBP-788210
troponin T2, cardiac
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118194:
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:135836354-135852260
Strand Forward strand
Band E4
Transcripts
ENSMUST00000027671 ENSMUSP00000027671
ENSMUST00000112087 ENSMUSP00000107717
ENSMUST00000112086 ENSMUSP00000107716
ENSMUST00000112085 ENSMUSP00000107715
ENSMUST00000178204 ENSMUSP00000137579
ENSMUST00000179863 ENSMUSP00000137093
ENSMUST00000178854 ENSMUSP00000136265
ENSMUST00000188028 ENSMUSP00000140941
ENSMUST00000191055
ENSMUST00000186225
ENSMUST00000190451 ENSMUSP00000140282
ENSMUST00000189732 ENSMUSP00000139669
ENSMUST00000189355 ENSMUSP00000139919
ENSMUST00000189826 ENSMUSP00000140807
ENSMUST00000188098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005523 tropomyosin binding
GO:0016887 ATPase activity
GO:0030172 troponin C binding
GO:0031013 troponin I binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0007507 heart development
GO:0008016 regulation of heart contraction
GO:0030049 muscle filament sliding
GO:0032780 negative regulation of ATPase activity
GO:0032781 positive regulation of ATPase activity
GO:0045214 sarcomere organization
GO:0051592 response to calcium ion
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005861 troponin complex
GO:0005865 striated muscle thin filament
GO:0030016 myofibril
GO:0030017 sarcomere
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118194
View Gene Order
ENSBTAG00000045789
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.247470
RefSeq NM_001130174 NM_001130175 NM_001130176 NM_001130177 NM_001130178 NM_001130179 NM_001130180 NM_001130181 NM_011619 XM_006529383 XM_006529384 XM_006529385 XM_006529386 XM_006529387 XM_006529388 XM_006529389 XM_006529390 XM_006529391 XM_006529392 XM_006529393 XM_006529394 XM_006529395
OMIM
CCDS CCDS48375 CCDS48376 CCDS48377 CCDS48378
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca