Version 5.4
Homo sapiens Gene: PLIN3
Summary
InnateDB Gene IDBG-19538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLIN3
Gene Name perilipin 3
Synonyms M6PRBP1; PP17; TIP47
Species Homo sapiens
Ensembl Gene ENSG00000105355
Encoded Proteins
IDBP-19540
perilipin 3
IDBP-766286
IDBP-763177
IDBP-759825
IDBP-763164
IDBP-762188
IDBP-760268
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4838341-4867768
Strand Reverse strand
Band p13.3
Transcripts
ENST00000221957 ENSP00000221957
ENST00000592528 ENSP00000467803
ENST00000589034 ENSP00000465975
ENST00000589494 ENSP00000468096
ENST00000589163 ENSP00000468476
ENST00000587462 ENSP00000465117
ENST00000585479 ENSP00000465596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005811 lipid particle
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024197
View Gene Order
ENSBTAG00000011805
Not yet available
Cross-References
SwissProt
TrEMBL K7EL96
UniProt Splice Variant
Entrez Gene 10226
UniGene Hs.140452
RefSeq NM_001164189 NM_001164194 NM_005817
HUGO HGNC:16893
OMIM 602702
CCDS CCDS12137 CCDS59337 CCDS59338
HPRD 04080
IMGT
EMBL AC027319
GenPept
RNA Seq Atlas 10226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca