Version 5.4
Mus musculus Gene: Eps8
Summary
InnateDB Gene IDBG-195386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eps8
Gene Name epidermal growth factor receptor pathway substrate 8
Synonyms AW261790
Species Mus musculus
Ensembl Gene ENSMUSG00000015766
Encoded Proteins
IDBP-195388
epidermal growth factor receptor pathway substrate 8
IDBP-195390
epidermal growth factor receptor pathway substrate 8
IDBP-257187
epidermal growth factor receptor pathway substrate 8
IDBP-537811
epidermal growth factor receptor pathway substrate 8
IDBP-541530
epidermal growth factor receptor pathway substrate 8
IDBP-534623
epidermal growth factor receptor pathway substrate 8
IDBP-534185
epidermal growth factor receptor pathway substrate 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22493489
Eps8 is a key regulator of the LPS-induced Tlr4-Myd88 interaction and directly contributes to phagocytosis in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 22493489
[Homo sapiens] EPS8 is a key regulator of the LPS-induced TLR4-MYD88 interaction and directly contributes to phagocytosis in macrophages. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151491:
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:137477245-137654876
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000058210 ENSMUSP00000052776
ENSMUST00000100841 ENSMUSP00000098402
ENSMUST00000111878 ENSMUSP00000107509
ENSMUST00000130274
ENSMUST00000147526 ENSMUSP00000120044
ENSMUST00000127179
ENSMUST00000132920 ENSMUSP00000122517
ENSMUST00000152046
ENSMUST00000146442 ENSMUSP00000119997
ENSMUST00000153933
ENSMUST00000139753
ENSMUST00000134630 ENSMUSP00000120648
ENSMUST00000156916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0008344 adult locomotory behavior
GO:0008360 regulation of cell shape
GO:0010458 exit from mitosis
GO:0016601 Rac protein signal transduction
GO:0030832 regulation of actin filament length
GO:0031532 actin cytoskeleton reorganization
GO:0036336 dendritic cell migration
GO:0045087 innate immune response (InnateDB)
GO:0048149 behavioral response to ethanol
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
GO:0051764 actin crosslink formation
GO:0070358 actin polymerization-dependent cell motility
Cellular Component
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030426 growth cone
GO:0032420 stereocilium
GO:0032587 ruffle membrane
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151491
View Gene Order
ENSBTAG00000000369
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
erbb1_downstream_pathway
ErbB1 downstream signaling
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q08509
TrEMBL D3Z7F4 Q3U2Z5 Q3UGL1
UniProt Splice Variant
Entrez Gene 13860
UniGene Mm.235346 Mm.412332 Mm.488641
RefSeq NM_001271587 NM_001271588 NM_001271589 NM_001271595 NM_007945 XM_006505507 XM_006505508
OMIM
CCDS CCDS20665
HPRD
IMGT
MGI ID MGI:104684
MGI Symbol Eps8
EMBL AC093120 AC166347 AK147877 AK149683 AK155022 AK166156 BC016890 L21671
GenPept AAA16358 AAH16890 BAE28197 BAE29023 BAE32995 BAE38601
RNA Seq Atlas 13860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca