Version 5.4
Mus musculus Gene: Wfdc1
Summary
InnateDB Gene IDBG-195736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wfdc1
Gene Name WAP four-disulfide core domain 1
Synonyms 2310058A03Rik; ps20
Species Mus musculus
Ensembl Gene ENSMUSG00000023336
Encoded Proteins
IDBP-195738
WAP four-disulfide core domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103175:
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119666523-119688222
Strand Forward strand
Band E1
Transcripts
ENSMUST00000024107 ENSMUSP00000024107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0010951 negative regulation of endopeptidase activity
GO:0032355 response to estradiol
GO:0042493 response to drug
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000103175
View Gene Order
Cross-References
SwissProt Q9ESH5
TrEMBL B7ZNL1 Q3UQ76
UniProt Splice Variant
Entrez Gene 67866
UniGene Mm.87599
RefSeq NM_023395
OMIM
CCDS CCDS22711
HPRD
IMGT
MGI ID MGI:1915116
MGI Symbol Wfdc1
EMBL AF169632 AF170446 AK132541 AK142707 AK161606 BC025850 BC132073 BC132469 BC145305 CH466525
GenPept AAG21086 AAH25850 AAI32074 AAI32470 AAI45306 BAE21228 BAE25167 BAE36489 EDL11610
RNA Seq Atlas 67866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca