Version 5.4
Mus musculus Gene: Cotl1
Summary
InnateDB Gene IDBG-195955.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cotl1
Gene Name coactosin-like 1 (Dictyostelium)
Synonyms 1810074P22Rik; 2010004C08Rik; Clp
Species Mus musculus
Ensembl Gene ENSMUSG00000031827
Encoded Proteins
IDBP-195957
coactosin-like 1 (Dictyostelium)
IDBP-623135
coactosin-like 1 (Dictyostelium)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103187:
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119809225-119840579
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000034285 ENSMUSP00000034285
ENSMUST00000168698 ENSMUSP00000126329
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0050832 defense response to fungus
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103187
View Gene Order
ENSBTAG00000016315
Not yet available
Cross-References
SwissProt Q9CQI6
TrEMBL Q544F6
UniProt Splice Variant
Entrez Gene 72042
UniGene Mm.393405 Mm.408051 Mm.468961
RefSeq NM_028071
OMIM
CCDS CCDS22712
HPRD
IMGT
MGI ID MGI:1919292
MGI Symbol Cotl1
EMBL AK007994 AK008085 AK010052 AK039644 AK148854 AK150888 AK151690 AK157694 AK172403 BC010249 BC011068 CT010261
GenPept AAH10249 AAH11068 BAB25396 BAB25450 BAB26668 BAC30407 BAE28680 BAE29935 BAE30614 BAE34154 BAE42989 CAJ18469
RNA Seq Atlas 72042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca