InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcc9

Summary

InnateDB Gene

IDBG-197029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcc9

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Synonyms

AI414027; AI449286; Sur2; SUR2A; SUR2B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030249

Encoded Proteins

IDBP-197031

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

IDBP-197033

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

IDBP-197035

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

IDBP-257397

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in four known transcript variants and several other variants that have not yet been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:142587862-142702274

Strand

Reverse strand

Band

Transcripts

ENSMUST00000100827	ENSMUSP00000098390
ENSMUST00000087527	ENSMUSP00000084805
ENSMUST00000073173	ENSMUSP00000072914
ENSMUST00000111771	ENSMUSP00000107401

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005267	potassium channel activity
GO:0005524	ATP binding
GO:0008281	sulfonylurea receptor activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0044325	ion channel binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007165	signal transduction
GO:0051607	defense response to virus
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0042383	sarcolemma