InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stat2

Summary

InnateDB Gene

IDBG-197036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat2

Gene Name

signal transducer and activator of transcription 2

Synonyms

1600010G07Rik; AW496480

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040033

Encoded Proteins

IDBP-197038

signal transducer and activator of transcription 2

IDBP-271304

signal transducer and activator of transcription 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26335850

Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.

InnateDB Annotation from Orthologs

Summary

PMID 8943351

[Homo sapiens] STAT2 is part of STAT-containing transcription factor, the alpha-interferon-induced ISGF3, that is composed of a STAT1:2 heterodimer and a weak DNA-binding protein, IRF9.

PMID 16689942

[Homo sapiens] STAT2 is a critical transactivator component of the interferon-stimulated gene factor 3 (ISGF3) complex that drives the expression of many interferon (IFN)-inducible genes.

PMID 23391734

[Homo sapiens] A loss-of-function mutation in STAT2 is associated with increased susceptibility to childhood viral diseases.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170581:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128270576-128292849

Strand

Forward strand

Band

Transcripts

ENSMUST00000085708	ENSMUSP00000082855
ENSMUST00000105238	ENSMUSP00000100872

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	23 [view]
Protein-DNA	25 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)