Version 5.4
Mus musculus Gene: Il16
Summary
InnateDB Gene IDBG-197072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il16
Gene Name interleukin 16
Synonyms mKIAA4048
Species Mus musculus
Ensembl Gene ENSMUSG00000001741
Encoded Proteins
IDBP-197074
interleukin 16
IDBP-532712
interleukin 16
IDBP-535577
interleukin 16
IDBP-533626
interleukin 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172349:
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:83642848-83745726
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000001792 ENSMUSP00000001792
ENSMUST00000145610
ENSMUST00000151047
ENSMUST00000153560 ENSMUSP00000118516
ENSMUST00000156553 ENSMUSP00000122813
ENSMUST00000131916 ENSMUSP00000122022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030595 leukocyte chemotaxis
GO:0050930 induction of positive chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172349
View Gene Order
ENSBTAG00000010963
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3Z3C7 D6RI15
UniProt Splice Variant
Entrez Gene 16170
UniGene Mm.10137 Mm.461598
RefSeq NM_010551 XM_006507384 XM_006507385 XM_006507386 XM_006507387
OMIM
CCDS CCDS21412
HPRD
IMGT
MGI ID MGI:1270855
MGI Symbol Il16
EMBL AC116389 AC158576
GenPept
RNA Seq Atlas 16170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca