Version 5.4
Mus musculus Gene: Il17c
Summary
InnateDB Gene IDBG-197277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17c
Gene Name interleukin 17C
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046108
Encoded Proteins
IDBP-197279
interleukin 17C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21993848
Il17c is an essential autocrine cytokine that regulates innate epithelial immune responses. (Demonstrated in human)
PMID 24412611
Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.
InnateDB Annotation from Orthologs
Summary
PMID 21993848
[Homo sapiens] IL17C is an essential autocrine cytokine that regulates innate epithelial immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124391:
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122422020-122423639
Strand Forward strand
Band E1
Transcripts
ENSMUST00000050963 ENSMUSP00000056008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0030223 neutrophil differentiation
GO:0045087 innate immune response (InnateDB)
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124391
View Gene Order
ENSBTAG00000047128
Not yet available
Cross-References
SwissProt Q8K4C5
TrEMBL
UniProt Splice Variant
Entrez Gene 234836
UniGene Mm.222808
RefSeq NM_145834
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:2446486
MGI Symbol Il17c
EMBL AF458061 AL591003 BC145853
GenPept AAI45854 AAM77565
RNA Seq Atlas 234836

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca