Version 5.4
| Mus musculus Gene: Aldh2 | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-197419.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Aldh2 | ||||||||||||||||||||||
| Gene Name | aldehyde dehydrogenase 2, mitochondrial | ||||||||||||||||||||||
| Synonyms | Ahd-5; Ahd5 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000029455 | ||||||||||||||||||||||
| Encoded Proteins |
aldehyde dehydrogenase 2, mitochondrial
aldehyde dehydrogenase 2, mitochondrial
|
||||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111275:
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011] This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50%% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011] |
||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 5:121566027-121593824 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | F | ||||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Phase 1 - Functionalization of compounds pathway
Serotonin clearance from the synaptic cleft pathway
Ethanol oxidation pathway
Metabolism pathway
Metabolism of serotonin pathway
Neurotransmitter Clearance In The Synaptic Cleft pathway
Neuronal System pathway
Biological oxidations pathway
Transmission across Chemical Synapses pathway
|
||||||||||||||||||||||
| KEGG |
beta-Alanine metabolism pathway
Valine, leucine and isoleucine degradation pathway
Histidine metabolism pathway
Ascorbate and aldarate metabolism pathway
Lysine degradation pathway
Glycolysis / Gluconeogenesis pathway
Arginine and proline metabolism pathway
Tryptophan metabolism pathway
Pentose and glucuronate interconversions pathway
Pyruvate metabolism pathway
Glycerolipid metabolism pathway
Fatty acid degradation pathway
|
||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Ethanol oxidation pathway
Metabolism of serotonin pathway
Neurotransmitter Clearance In The Synaptic Cleft pathway
Neuronal System pathway
Serotonin clearance from the synaptic cleft pathway
Transmission across Chemical Synapses pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
Neurotransmitter Clearance In The Synaptic Cleft pathway
Transmission across Chemical Synapses pathway
Phase 1 - Functionalization of compounds pathway
Biological oxidations pathway
Ethanol oxidation pathway
Neuronal System pathway
Metabolism pathway
Metabolism of serotonin pathway
Serotonin clearance from the synaptic cleft pathway
|
||||||||||||||||||||||
| KEGG |
Glycolysis / Gluconeogenesis pathway
Histidine metabolism pathway
Pyruvate metabolism pathway
Valine, leucine and isoleucine degradation pathway
Arginine and proline metabolism pathway
Tryptophan metabolism pathway
Pentose and glucuronate interconversions pathway
Fatty acid degradation pathway
Lysine degradation pathway
Ascorbate and aldarate metabolism pathway
beta-Alanine metabolism pathway
Glycerolipid metabolism pathway
|
||||||||||||||||||||||
| INOH |
Tryptophan degradation pathway
Propanoate metabolism pathway
Arginine Proline metabolism pathway
Pyruvate metabolism pathway
Valine Leucine Isoleucine degradation pathway
Lysine degradation pathway
Histidine degradation pathway
|
||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.284446 | ||||||||||||||||||||||
| RefSeq | NM_009656 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS19638 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||