InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gnat1

Summary

InnateDB Gene

IDBG-198118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnat1

Gene Name

guanine nucleotide binding protein, alpha transducing 1

Synonyms

Gnat-1; Ird1; Ird2; irdc; irdr; Tralpha; transducin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034837

Encoded Proteins

IDBP-198120

guanine nucleotide binding protein, alpha transducing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114349:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107674477-107679592

Strand

Reverse strand

Band

Transcripts

ENSMUST00000010205

ENSMUSP00000010205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0008283	cell proliferation
GO:0009642	response to light intensity
GO:0016056	rhodopsin mediated signaling pathway
GO:0042462	eye photoreceptor cell development
GO:0050908	detection of light stimulus involved in visual perception
GO:0050917	sensory perception of umami taste
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0060041	retina development in camera-type eye
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0005834	heterotrimeric G-protein complex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032391	photoreceptor connecting cilium
GO:0043025	neuronal cell body