Homo sapiens Gene: WNT7A
Summary
InnateDB Gene IDBG-19862.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT7A
Gene Name wingless-type MMTV integration site family, member 7A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154764
Encoded Proteins
wingless-type MMTV integration site family, member 7A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:13816258-13880121
Strand Reverse strand
Band p25.1
Transcripts
ENST00000285018 ENSP00000285018
ENST00000489346
ENST00000497808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0048018 receptor agonist activity
Biological Process
GO:0000578 embryonic axis specification
GO:0001502 cartilage condensation
GO:0002062 chondrocyte differentiation
GO:0007269 neurotransmitter secretion
GO:0007275 multicellular organismal development
GO:0007548 sex differentiation
GO:0008105 asymmetric protein localization
GO:0008284 positive regulation of cell proliferation
GO:0009953 dorsal/ventral pattern formation
GO:0014719 satellite cell activation
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016055 Wnt signaling pathway
GO:0021707 cerebellar granule cell differentiation
GO:0021846 cell proliferation in forebrain
GO:0022009 central nervous system vasculogenesis
GO:0030010 establishment of cell polarity
GO:0030182 neuron differentiation
GO:0030326 embryonic limb morphogenesis
GO:0031133 regulation of axon diameter
GO:0032355 response to estradiol
GO:0035019 somatic stem cell maintenance
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035567 non-canonical Wnt signaling pathway
GO:0035659 Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0042733 embryonic digit morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045165 cell fate commitment
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0048103 somatic stem cell division
GO:0048864 stem cell development
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050808 synapse organization
GO:0051216 cartilage development
GO:0051965 positive regulation of synapse assembly
GO:0060021 palate development
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060065 uterus development
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0061038 uterus morphogenesis
GO:0070307 lens fiber cell development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Wnt signaling network
Cross-References
SwissProt O00755
TrEMBL
UniProt Splice Variant
Entrez Gene 7476
UniGene Hs.609789 Hs.72290
RefSeq NM_004625
HUGO HGNC:12786
OMIM 601570
CCDS CCDS2616
HPRD
IMGT
EMBL BC008811 CH471055 D83175 U53476
GenPept AAC51319 AAH08811 BAA82509 EAW64173
RNA Seq Atlas 7476