Mus musculus Gene: Casc5
Summary
InnateDB Gene IDBG-198797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Casc5
Gene Name cancer susceptibility candidate 5
Synonyms 2310043D08Rik; 5730505K17Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000027326
Encoded Proteins
cancer susceptibility candidate 5
cancer susceptibility candidate 5
cancer susceptibility candidate 5
cancer susceptibility candidate 5
cancer susceptibility candidate 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137812:
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119047119-119105501
Strand Forward strand
Band E5
Transcripts
ENSMUST00000028799 ENSMUSP00000028799
ENSMUST00000099542 ENSMUSP00000097140
ENSMUST00000028802 ENSMUSP00000028802
ENSMUST00000152380 ENSMUSP00000118646
ENSMUST00000153300 ENSMUSP00000120905
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0010923 negative regulation of phosphatase activity
GO:0034501 protein localization to kinetochore
GO:0071173 spindle assembly checkpoint
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Chromosome Maintenance pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Cell Cycle pathway
M Phase pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Nucleosome assembly pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Mitotic Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSLP pathway
REACTOME
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.202518 Mm.481433
RefSeq NM_029617 XM_006500376 XM_006500377
OMIM
CCDS CCDS38203
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas