InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dag1

Summary

InnateDB Gene

IDBG-199494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dag1

Gene Name

dystroglycan 1

Synonyms

D9Wsu13e; DG; Dp427; Dp71

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039952

Encoded Proteins

IDBP-199498

dystroglycan 1

IDBP-626498

dystroglycan 1

IDBP-626499

dystroglycan 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173402:
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108205955-108263924

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080435	ENSMUSP00000079294
ENSMUST00000166905	ENSMUSP00000128531
ENSMUST00000171412	ENSMUSP00000130626

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0015631	tubulin binding
GO:0017166	vinculin binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0006509	membrane protein ectodomain proteolysis
GO:0006607	NLS-bearing protein import into nucleus
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0014044	Schwann cell development
GO:0016340	calcium-dependent cell-matrix adhesion
GO:0019048	modulation by virus of host morphology or physiology
GO:0021682	nerve maturation
GO:0022011	myelination in peripheral nervous system
GO:0030336	negative regulation of cell migration
GO:0034453	microtubule anchoring
GO:0043409	negative regulation of MAPK cascade
GO:0043434	response to peptide hormone
GO:0051898	negative regulation of protein kinase B signaling
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0071679	commissural neuron axon guidance
GO:0071711	basement membrane organization

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion
GO:0009279	cell outer membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016011	dystroglycan complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0033268	node of Ranvier
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome
GO:0070938	contractile ring