Mus musculus Gene: Cyp1b1
Summary
InnateDB Gene IDBG-199555.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp1b1
Gene Name cytochrome P450, family 1, subfamily b, polypeptide 1
Synonyms CP1B; P4501b1;
Species Mus musculus
Ensembl Gene ENSMUSG00000024087
Encoded Proteins
cytochrome P450, family 1, subfamily b, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138061:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:79706953-79715041
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000024894 ENSMUSP00000024894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0001525 angiogenesis
GO:0002930 trabecular meshwork development
GO:0006725 cellular aromatic compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007155 cell adhesion
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009404 toxin metabolic process
GO:0009636 response to toxic substance
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0019369 arachidonic acid metabolic process
GO:0030199 collagen fibril organization
GO:0030336 negative regulation of cell migration
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046466 membrane lipid catabolic process
GO:0048514 blood vessel morphogenesis
GO:0055114 oxidation-reduction process
GO:0061298 retina vasculature development in camera-type eye
GO:0061304 retinal blood vessel morphogenesis
GO:0070301 cellular response to hydrogen peroxide
GO:0071407 cellular response to organic cyclic compound
GO:0071603 endothelial cell-cell adhesion
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytochrome P450 - arranged by substrate type pathway
Phase 1 - Functionalization of compounds pathway
Metabolism pathway
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
Metabolism of lipids and lipoproteins pathway
Endogenous sterols pathway
Biological oxidations pathway
Arachidonic acid metabolism pathway
KEGG
Steroid hormone biosynthesis pathway
Tryptophan metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
Cytochrome P450 - arranged by substrate type pathway
Endogenous sterols pathway
Metabolism pathway
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Steroid hormone biosynthesis pathway
Tryptophan metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.214016 Mm.412970
RefSeq NM_009994
OMIM
CCDS CCDS28986
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas