Version 5.4
Mus musculus Gene: Nup133
Summary
InnateDB Gene IDBG-199804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nup133
Gene Name nucleoporin 133
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039509
Encoded Proteins
IDBP-199806
nucleoporin 133
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069248:
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123897123-123949265
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000044795 ENSMUSP00000048084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005487 nucleocytoplasmic transporter activity
GO:0005515 protein binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0006999 nuclear pore organization
GO:0015031 protein transport
GO:0048339 paraxial mesoderm development
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0000940 condensed chromosome outer kinetochore
GO:0005643 nuclear pore
GO:0016020 membrane
GO:0031080 nuclear pore outer ring
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069248
View Gene Order
ENSBTAG00000004965
Not yet available
Pathways
NETPATH
REACTOME
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_196650
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_204192
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_250557
Mitotic Prophase pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_202512
Mitotic Anaphase pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q8R0G9
TrEMBL
UniProt Splice Variant
Entrez Gene 234865
UniGene Mm.267812 Mm.414068
RefSeq NM_172288 XM_006530964
OMIM
CCDS CCDS22765
HPRD
IMGT
MGI ID MGI:2442620
MGI Symbol Nup133
EMBL AC123825 AC147266 BC023915 BC026845
GenPept AAH23915 AAH26845
RNA Seq Atlas 234865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca