Version 5.4
| Mus musculus Gene: Sos1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-199949.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Sos1 | ||||||||||||||||||||||
| Gene Name | son of sevenless homolog 1 (Drosophila) | ||||||||||||||||||||||
| Synonyms | 4430401P03Rik; 9630010N06; AI449023 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000024241 | ||||||||||||||||||||||
| Encoded Proteins |
son of sevenless homolog 1 (Drosophila)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115904:
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 17:80393752-80480453 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | E3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
Disease pathway
SHC-related events pathway
Hemostasis pathway
Signaling by constitutively active EGFR pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Regulation of KIT signaling pathway
EGFR Transactivation by Gastrin pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
NRAGE signals death through JNK pathway
Signal attenuation pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Signaling by Robo receptor pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
Signaling by Rho GTPases pathway
SHC1 events in EGFR signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Signaling by EGFR pathway
Insulin receptor signalling cascade pathway
G alpha (12/13) signalling events pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interleukin receptor SHC signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Rho GTPase cycle pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Signaling by FGFR mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SHC-mediated cascade pathway
SOS-mediated signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Tie2 Signaling pathway
p75 NTR receptor-mediated signalling pathway
Integrin alphaIIb beta3 signaling pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
Platelet Aggregation (Plug Formation) pathway
FCERI mediated MAPK activation pathway
SHC-related events triggered by IGF1R pathway
Activation of Rac pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Gap junction pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
GnRH signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Glioma pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Dorso-ventral axis formation pathway
Pathways in cancer pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF8 signaling (Mouse) pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
Prolactin pathway
Oncostatin_M pathway
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| REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Signalling to RAS pathway
NRAGE signals death through JNK pathway
SOS-mediated signalling pathway
Signal attenuation pathway
SHC1 events in EGFR signaling pathway
GRB2 events in EGFR signaling pathway
Signaling by EGFR pathway
EGFR Transactivation by Gastrin pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (12/13) signalling events pathway
SHC1 events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
Rho GTPase cycle pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
SHC-mediated cascade pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by constitutively active EGFR pathway
Signaling by FGFR mutants pathway
NCAM signaling for neurite out-growth pathway
Activation of Rac pathway
Signaling by Robo receptor pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by Rho GTPases pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
IGF1R signaling cascade pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
GnRH signaling pathway pathway
Acute myeloid leukemia pathway
Fc epsilon RI signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Endometrial cancer pathway
Glioma pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Dorso-ventral axis formation pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
TCR signaling in naïve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Regulation of RAC1 activity
IL2-mediated signaling events
TCR signaling in naïve CD4+ T cells
Internalization of ErbB1
VEGFR3 signaling in lymphatic endothelium
ErbB1 downstream signaling
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
BCR signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
Regulation of Ras family activation
ErbB2/ErbB3 signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
TGF-beta receptor signaling
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
Insulin Pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | Q62245 | ||||||||||||||||||||||
| TrEMBL | Q2M4G6 Q9JKM6 Q9QYS7 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 20662 | ||||||||||||||||||||||
| UniGene | Mm.360004 | ||||||||||||||||||||||
| RefSeq | NM_009231 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS37704 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:98354 | ||||||||||||||||||||||
| MGI Symbol | Sos1 | ||||||||||||||||||||||
| EMBL | AF233591 AH008383 AY902349 Z11574 Z11578 | ||||||||||||||||||||||
| GenPept | AAF08009 AAF42937 AAY21059 CAA77662 CAA77665 | ||||||||||||||||||||||
| RNA Seq Atlas | 20662 | ||||||||||||||||||||||