InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Inpp5k

Summary

InnateDB Gene

IDBG-200304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inpp5k

Gene Name

inositol polyphosphate 5-phosphatase K

Synonyms

C62; Pps; SKIP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006127

Encoded Proteins

IDBP-200306

inositol polyphosphate 5-phosphatase K

IDBP-540876

inositol polyphosphate 5-phosphatase K

IDBP-538786

inositol polyphosphate 5-phosphatase K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132376:
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75630988-75648871

Strand

Forward strand

Band

Transcripts

ENSMUST00000006286	ENSMUSP00000006286
ENSMUST00000136605
ENSMUST00000129298
ENSMUST00000150857	ENSMUSP00000119996
ENSMUST00000130318
ENSMUST00000149134
ENSMUST00000139856	ENSMUSP00000121060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding
GO:0016312	inositol bisphosphate phosphatase activity
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
GO:0046030	inositol trisphosphate phosphatase activity
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001933	negative regulation of protein phosphorylation
GO:0005979	regulation of glycogen biosynthetic process
GO:0006469	negative regulation of protein kinase activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010829	negative regulation of glucose transport
GO:0016311	dephosphorylation
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035305	negative regulation of dephosphorylation
GO:0035810	positive regulation of urine volume
GO:0042593	glucose homeostasis
GO:0043407	negative regulation of MAP kinase activity
GO:0043922	negative regulation by host of viral transcription
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0051497	negative regulation of stress fiber assembly
GO:0051898	negative regulation of protein kinase B signaling
GO:0051926	negative regulation of calcium ion transport
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072661	protein targeting to plasma membrane
GO:0090315	negative regulation of protein targeting to membrane
GO:0097178	ruffle assembly
GO:2000466	negative regulation of glycogen (starch) synthase activity
GO:2001153	positive regulation of renal water transport

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm