Mus musculus Gene: Cdk2ap1
Summary
InnateDB Gene IDBG-200577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk2ap1
Gene Name CDK2 (cyclin-dependent kinase 2)-associated protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029394
Encoded Proteins
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111328:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:124345417-124354671
Strand Reverse strand
Band F
Transcripts
ENSMUST00000031341 ENSMUSP00000031341
ENSMUST00000111474 ENSMUSP00000107099
ENSMUST00000111473 ENSMUSP00000107098
ENSMUST00000111472 ENSMUSP00000107097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL F2Z4B3
UniProt Splice Variant
Entrez Gene 13445
UniGene Mm.425284
RefSeq NM_013812
OMIM
CCDS CCDS39279
HPRD
IMGT
MGI ID MGI:1202069
MGI Symbol Cdk2ap1
EMBL AC127339
GenPept
RNA Seq Atlas 13445