Version 5.4
| Mus musculus Gene: Cdk2ap1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-200577.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Cdk2ap1 | ||||||||
| Gene Name | CDK2 (cyclin-dependent kinase 2)-associated protein 1 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000029394 | ||||||||
| Encoded Proteins |
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111328:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:124345417-124354671 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | F | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | O35207 | ||||||||
| TrEMBL | F2Z4B3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 13445 | ||||||||
| UniGene | Mm.425284 | ||||||||
| RefSeq | NM_013812 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS39279 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1202069 | ||||||||
| MGI Symbol | Cdk2ap1 | ||||||||
| EMBL | AC127339 AF011644 AK004852 AL645849 BC083075 BC103772 BC147052 BC147053 | ||||||||
| GenPept | AAB65752 AAH83075 AAI03773 AAI47053 AAI47054 BAB23616 CAI35111 | ||||||||
| RNA Seq Atlas | 13445 | ||||||||