InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgat2

Summary

InnateDB Gene

IDBG-200580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgat2

Gene Name

diacylglycerol O-acyltransferase 2

Synonyms

0610010B06Rik; ARAT; DGAT-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030747

Encoded Proteins

IDBP-200582

diacylglycerol O-acyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062282:
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:99153663-99182713

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033001

ENSMUSP00000033001

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803	protein homodimerization activity
GO:0050252	retinol O-fatty-acyltransferase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0019915	lipid storage
GO:0034383	low-density lipoprotein particle clearance
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0035356	cellular triglyceride homeostasis
GO:0042572	retinol metabolic process
GO:0042632	cholesterol homeostasis
GO:0046339	diacylglycerol metabolic process
GO:0055089	fatty acid homeostasis
GO:0060613	fat pad development
GO:0071400	cellular response to oleic acid
GO:0097006	regulation of plasma lipoprotein particle levels

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm