Version 5.4
Mus musculus Gene: Slc26a6
Summary
InnateDB Gene IDBG-200670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc26a6
Gene Name solute carrier family 26, member 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000023259
Encoded Proteins
IDBP-200676
solute carrier family 26, member 6
IDBP-790070
solute carrier family 26, member 6
IDBP-790072
solute carrier family 26, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000225697:
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108854037-108913049
Strand Forward strand
Band F2
Transcripts
ENSMUST00000098376 ENSMUSP00000095979
ENSMUST00000188557 ENSMUSP00000140849
ENSMUST00000191404 ENSMUSP00000140982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0015499 formate transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015659 formate uptake transmembrane transporter activity
GO:0015660 formate efflux transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0015724 formate transport
GO:0015797 mannitol transport
GO:0019532 oxalate transport
GO:0030321 transepithelial chloride transport
GO:0038166 angiotensin-activated signaling pathway
GO:0042045 epithelial fluid transport
GO:0046724 oxalic acid secretion
GO:0048240 sperm capacitation
GO:0050892 intestinal absorption
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0070528 protein kinase C signaling
GO:0070633 transepithelial transport
GO:0071320 cellular response to cAMP
GO:0071332 cellular response to fructose stimulus
GO:0071346 cellular response to interferon-gamma
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
GO:2001150 positive regulation of dipeptide transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031526 brush border membrane
GO:0031988 membrane-bounded vesicle
GO:0034707 chloride channel complex
GO:0097225 sperm midpiece
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000225697
View Gene Order
ENSBTAG00000038381
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19357
Multifunctional anion exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_134420
OMIM
CCDS
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca