InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v0a2

Summary

InnateDB Gene

IDBG-200994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0a2

Gene Name

ATPase, H+ transporting, lysosomal V0 subunit A2

Synonyms

8430408C20Rik; AI385560; ATP6a2; Atp6n1d; Atp6n2; AW489264; C76904; ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa; V-ATPase a2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038023

Encoded Proteins

IDBP-200996

ATPase, H+ transporting, lysosomal V0 subunit A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of vacuolar ATPase, a multimeric enzyme that localizes to intracellular vesicles and to the plasma membrane of specialized cells. The encoded protein is a component of the V(0) domain, which functions in proton translocation across membranes. Function of this gene is important in fetal-specific immune suppression during pregnancy. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:124629067-124722144

Strand

Forward strand

Band

Transcripts

ENSMUST00000037865

ENSMUSP00000039737

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain