Mus musculus Gene: Pold3
Summary
InnateDB Gene IDBG-201018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pold3
Gene Name polymerase (DNA-directed), delta 3, accessory subunit
Synonyms 2410142G14Rik; C85233; P66; P68;
Species Mus musculus
Ensembl Gene ENSMUSG00000030726
Encoded Proteins
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077514:
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100082111-100121565
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000032969 ENSMUSP00000032969
ENSMUST00000127128 ENSMUSP00000115707
ENSMUST00000130413
ENSMUST00000156518
ENSMUST00000123675
ENSMUST00000129556
ENSMUST00000156202
ENSMUST00000149104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Removal of the Flap Intermediate from the C-strand pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Removal of DNA patch containing abasic residue pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Polymerase switching pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Removal of the Flap Intermediate from the C-strand pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Removal of DNA patch containing abasic residue pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Base Excision Repair pathway
Processive synthesis on the lagging strand pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Processive synthesis on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RG54
UniProt Splice Variant
Entrez Gene 67967
UniGene Mm.37562 Mm.397759
RefSeq NM_133692 XM_006508150 XM_006508149
OMIM
CCDS CCDS21493
HPRD
IMGT
MGI ID MGI:1915217
MGI Symbol Pold3
EMBL AC161205
GenPept
RNA Seq Atlas 67967