InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P4ha3

Summary

InnateDB Gene

IDBG-201148.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4ha3

Gene Name

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051048

Encoded Proteins

IDBP-201152

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

IDBP-541528

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

IDBP-539399

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149380:
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100285520-100319699

Strand

Forward strand

Band

Transcripts

ENSMUST00000057023	ENSMUSP00000055297
ENSMUST00000139790	ENSMUSP00000117015
ENSMUST00000148620
ENSMUST00000138465	ENSMUSP00000119159

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0019511	peptidyl-proline hydroxylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005575	cellular_component
GO:0005783	endoplasmic reticulum

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000149380

View Gene Order

ENSBTAG00000006579

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00330

Arginine and proline metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D6RFD3

UniProt Splice Variant

Entrez Gene

320452

UniGene

Mm.150294

RefSeq

NM_177161

OMIM

CCDS

CCDS21496

HPRD

IMGT

MGI ID

MGI:2444049

MGI Symbol

P4ha3

EMBL

AC122269

GenPept

RNA Seq Atlas

320452