Version 5.4
Mus musculus Gene: Ssh2
Summary
InnateDB Gene IDBG-201408.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ssh2
Gene Name slingshot homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037926
Encoded Proteins
IDBP-201410
slingshot homolog 2 (Drosophila)
IDBP-535576
slingshot homolog 2 (Drosophila)
IDBP-718770
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141298:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77216287-77460220
Strand Forward strand
Band B5
Transcripts
ENSMUST00000037912 ENSMUSP00000042625
ENSMUST00000156488 ENSMUSP00000119681
ENSMUST00000127890
ENSMUST00000181283 ENSMUSP00000137933
ENSMUST00000180394
ENSMUST00000180554
ENSMUST00000180545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0030036 actin cytoskeleton organization
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141298
View Gene Order
ENSBTAG00000011011
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 237860
UniGene Mm.406255 Mm.440381 Mm.443360 Mm.475485
RefSeq NM_001291190 NM_177710 XM_006533227 XM_006533228 XM_006533229 XM_006533230
OMIM
CCDS CCDS25076 CCDS70248
HPRD
IMGT
MGI ID MGI:2679255
MGI Symbol Ssh2
EMBL
GenPept
RNA Seq Atlas 237860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca