Mus musculus Gene: Ucp2 | |||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-201460.6 | ||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
Gene Symbol | Ucp2 | ||||||||||||||||||||||||||||||||
Gene Name | uncoupling protein 2 (mitochondrial, proton carrier) | ||||||||||||||||||||||||||||||||
Synonyms | Slc25a8 | ||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000033685 | ||||||||||||||||||||||||||||||||
Encoded Proteins |
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
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Protein Structure | |||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] MIR133A1 enhances CASP1 activation and IL1B processing and suppresses inflammasome activation by suppressing its target UCP2
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Entrez Gene | |||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175567:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008] Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5\'-UCP3-UCP2-3\'. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 7:100493337-100502020 | ||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||
Band | E2 | ||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||
REACTOME |
The proton buffering model pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The fatty acid cycling model pathway
Mitochondrial Uncoupling Proteins pathway
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KEGG | |||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||
REACTOME |
The fatty acid cycling model pathway
The proton buffering model pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial Uncoupling Proteins pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
The fatty acid cycling model pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
The proton buffering model pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial Uncoupling Proteins pathway
Metabolism pathway
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KEGG | |||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
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Cross-References | |||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||
UniGene | Mm.171378 | ||||||||||||||||||||||||||||||||
RefSeq | NM_011671 XM_006507579 | ||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||
CCDS | CCDS21498 | ||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||