Mus musculus Gene: Ubr1
Summary
InnateDB Gene IDBG-201465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubr1
Gene Name ubiquitin protein ligase E3 component n-recognin 1
Synonyms AI504731;
Species Mus musculus
Ensembl Gene ENSMUSG00000027272
Encoded Proteins
ubiquitin protein ligase E3 component n-recognin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159459:
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120860269-120970715
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000028728 ENSMUSP00000028728
ENSMUST00000153868
ENSMUST00000135891
ENSMUST00000129790
ENSMUST00000154023
ENSMUST00000133408
ENSMUST00000138824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0070728 leucine binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0032007 negative regulation of TOR signaling
GO:0071233 cellular response to leucine
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000502 proteasome complex
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O70481
TrEMBL Q3TKQ2
UniProt Splice Variant
Entrez Gene 22222
UniGene Mm.389330
RefSeq NM_009461 XM_006499164
OMIM
CCDS CCDS16628
HPRD
IMGT
MGI ID MGI:1277977
MGI Symbol Ubr1
EMBL AF061555 AH006182 AK078173 AK089616 AK166885 AL844548 AL935168 BC090969
GenPept AAC23678 AAC40165 AAH90969 BAC37160 BAC40933 BAE39093 CAM19009 CAM21400
RNA Seq Atlas 22222