InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ubr1

Summary

InnateDB Gene

IDBG-201465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubr1

Gene Name

ubiquitin protein ligase E3 component n-recognin 1

Synonyms

AI504731

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027272

Encoded Proteins

IDBP-201467

ubiquitin protein ligase E3 component n-recognin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159459:
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:120860269-120970715

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028728	ENSMUSP00000028728
ENSMUST00000153868
ENSMUST00000135891
ENSMUST00000129790
ENSMUST00000154023
ENSMUST00000133408
ENSMUST00000138824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0070728	leucine binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0032007	negative regulation of TOR signaling
GO:0071233	cellular response to leucine

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000502	proteasome complex
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159459

View Gene Order

ENSBTAG00000021087

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.389330

RefSeq

NM_009461 XM_006499164

OMIM

CCDS

CCDS16628

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas