InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo11

Summary

InnateDB Gene

IDBG-201588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo11

Gene Name

F-box protein 11

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005371

Encoded Proteins

IDBP-201590

F-box protein 11

IDBP-531777

F-box protein 11

IDBP-788013

F-box protein 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138081:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:87990859-88065291

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005504	ENSMUSP00000005504
ENSMUST00000130379	ENSMUSP00000121206
ENSMUST00000135639	ENSMUSP00000138653
ENSMUST00000127334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016274	protein-arginine N-methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0007605	sensory perception of sound
GO:0016567	protein ubiquitination
GO:0035246	peptidyl-arginine N-methylation

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138081

View Gene Order

ENSBTAG00000001425

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.386857 Mm.487299

RefSeq

NM_001081034 XM_006524203 XM_006524204

OMIM

CCDS

CCDS37717

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas