InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scap

Summary

InnateDB Gene

IDBG-201997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scap

Gene Name

SREBF chaperone

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032485

Encoded Proteins

IDBP-202001

SREBF chaperone

IDBP-535456

SREBF chaperone

IDBP-534278

SREBF chaperone

IDBP-533859

SREBF chaperone

IDBP-539796

SREBF chaperone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114650:
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:110333288-110384946

Strand

Forward strand

Band

Transcripts

ENSMUST00000098350	ENSMUSP00000095953
ENSMUST00000152154
ENSMUST00000131328	ENSMUSP00000114962
ENSMUST00000133114	ENSMUSP00000115671
ENSMUST00000125759	ENSMUSP00000123366
ENSMUST00000142100	ENSMUSP00000123182
ENSMUST00000128730
ENSMUST00000151299
ENSMUST00000141688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0015485	cholesterol binding
GO:0032403	protein complex binding

Biological Process

GO:0001666	response to hypoxia
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0019217	regulation of fatty acid metabolic process
GO:0032868	response to insulin
GO:0032933	SREBP signaling pathway
GO:0042304	regulation of fatty acid biosynthetic process
GO:0045540	regulation of cholesterol biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114650

View Gene Order

ENSBTAG00000015782

Not yet available

Pathways

NETPATH

REACTOME

REACT_198968

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_188937

Metabolism pathway

REACT_232291

Metabolism of lipids and lipoproteins pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001001144 NM_001103162 XM_006512083 XM_006512084 XM_006512085 XM_006512086

OMIM

CCDS

CCDS23564

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas