Version 5.4
Mus musculus Gene: Folr1
Summary
InnateDB Gene IDBG-202269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Folr1
Gene Name folate receptor 1 (adult)
Synonyms FBP1; Folbp-1; Folbp1
Species Mus musculus
Ensembl Gene ENSMUSG00000001827
Encoded Proteins
IDBP-202271
folate receptor 1 (adult)
IDBP-267626
folate receptor 1 (adult)
IDBP-267628
folate receptor 1 (adult)
IDBP-267630
folate receptor 1 (adult)
IDBP-267632
folate receptor 1 (adult)
IDBP-267634
folate receptor 1 (adult)
IDBP-533452
folate receptor 1 (adult)
IDBP-540525
folate receptor 1 (adult)
IDBP-537572
folate receptor 1 (adult)
IDBP-535062
folate receptor 1 (adult)
IDBP-536339
folate receptor 1 (adult)
IDBP-539031
folate receptor 1 (adult)
IDBP-541515
folate receptor 1 (adult)
IDBP-540985
folate receptor 1 (adult)
IDBP-540975
folate receptor 1 (adult)
IDBP-542688
folate receptor 1 (adult)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110195:
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101858331-101870788
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000001882 ENSMUSP00000001882
ENSMUST00000106986 ENSMUSP00000102599
ENSMUST00000106985 ENSMUSP00000102598
ENSMUST00000106983 ENSMUSP00000102596
ENSMUST00000106982 ENSMUSP00000102595
ENSMUST00000106981 ENSMUSP00000102594
ENSMUST00000140068 ENSMUSP00000114633
ENSMUST00000151706 ENSMUSP00000115077
ENSMUST00000126204 ENSMUSP00000117175
ENSMUST00000134145 ENSMUSP00000118547
ENSMUST00000123630 ENSMUSP00000121947
ENSMUST00000123321 ENSMUSP00000114167
ENSMUST00000155311 ENSMUSP00000115360
ENSMUST00000150184 ENSMUSP00000114919
ENSMUST00000140584 ENSMUSP00000116068
ENSMUST00000124026 ENSMUSP00000121374
ENSMUST00000125298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005542 folic acid binding
GO:0008517 folic acid transporter activity
Biological Process
GO:0006620 posttranslational protein targeting to membrane
GO:0015884 folic acid transport
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005903 brush border
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031362 anchored component of external side of plasma membrane
GO:0031526 brush border membrane
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110195
View Gene Order
ENSBTAG00000038532
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z711 E9Q3D3 Q9R223
UniProt Splice Variant
Entrez Gene 14275
UniGene Mm.2135
RefSeq NM_001252552 NM_001252553 NM_001252554 NM_008034 XM_006507360 XM_006507361 XM_006507362 XM_006507363 XM_006507364 XM_006507365 XM_006507366 XM_006507367 XM_006507368 XM_006507369 XM_006507370
OMIM
CCDS CCDS21517
HPRD
IMGT
MGI ID MGI:95568
MGI Symbol Folr1
EMBL AC167240 AF096320
GenPept AAD19354
RNA Seq Atlas 14275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca