Version 5.4
Mus musculus Gene: Cd247
Summary
InnateDB Gene IDBG-202777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd247
Gene Name CD247 antigen
Synonyms 4930549J05Rik; A430104F18Rik; AW552088; Cd3; Cd3-eta; Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz
Species Mus musculus
Ensembl Gene ENSMUSG00000005763
Encoded Proteins
IDBP-202779
CD247 antigen
IDBP-202781
CD247 antigen
IDBP-202783
CD247 antigen
IDBP-536156
CD247 antigen
IDBP-531660
CD247 antigen
IDBP-717078
IDBP-788198
CD247 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198821:
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:165788681-165877277
Strand Forward strand
Band H2.3
Transcripts
ENSMUST00000005907 ENSMUSP00000005907
ENSMUST00000027849 ENSMUSP00000027849
ENSMUST00000086002 ENSMUSP00000083165
ENSMUST00000161971 ENSMUSP00000124297
ENSMUST00000161559 ENSMUSP00000124299
ENSMUST00000159070
ENSMUST00000162411
ENSMUST00000178336 ENSMUSP00000136456
ENSMUST00000187313 ENSMUSP00000140926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198821
View Gene Order
ENSBTAG00000012700
Not yet available
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_225145
Downstream TCR signaling pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_196487
FCGR activation pathway
REACT_215414
Translocation of ZAP-70 to Immunological synapse pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04660
T cell receptor signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL A2MZG6
UniProt Splice Variant
Entrez Gene 12503
UniGene
RefSeq NM_001113393 NM_001113391 NM_001113392 NM_001113394 NM_031162 XM_006496633 XM_006496634
OMIM
CCDS CCDS48428 CCDS15443 CCDS48427 CCDS48429
HPRD
IMGT
MGI ID MGI:88334
MGI Symbol Cd247
EMBL AC090495 AC093371 AC124587 L03353
GenPept AAA37401
RNA Seq Atlas 12503

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca