Version 5.4
Mus musculus Gene: Duoxa1
Summary
InnateDB Gene IDBG-202903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Duoxa1
Gene Name dual oxidase maturation factor 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027224
Encoded Proteins
IDBP-202905
dual oxidase maturation factor 1
IDBP-260073
dual oxidase maturation factor 1
IDBP-260075
dual oxidase maturation factor 1
IDBP-533164
dual oxidase maturation factor 1
IDBP-534732
dual oxidase maturation factor 1
IDBP-535975
dual oxidase maturation factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140254:
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:122302191-122313730
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000028653 ENSMUSP00000028653
ENSMUST00000110538 ENSMUSP00000106167
ENSMUST00000110537 ENSMUSP00000106166
ENSMUST00000155561
ENSMUST00000148417 ENSMUSP00000116963
ENSMUST00000147788 ENSMUSP00000116280
ENSMUST00000154412 ENSMUSP00000116911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0042743 hydrogen peroxide metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0050727 regulation of inflammatory response
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000609 regulation of thyroid hormone generation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140254
View Gene Order
ENSBTAG00000016242
Not yet available
Cross-References
SwissProt
TrEMBL A2AQ93 A2AQ94 A2AQ95
UniProt Splice Variant
Entrez Gene 213696
UniGene Mm.247121
RefSeq NM_145395 XM_006499091 XM_006499092 XM_006499093
OMIM
CCDS CCDS16661
HPRD
IMGT
MGI ID MGI:2384861
MGI Symbol Duoxa1
EMBL AL844566 CH466519
GenPept EDL28099
RNA Seq Atlas 213696

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca