Homo sapiens Gene: CDKN1B
Summary
InnateDB Gene IDBG-20317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKN1B
Gene Name cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms CDKN4; KIP1; MEN1B; MEN4; P27KIP1;
Species Homo sapiens
Ensembl Gene ENSG00000111276
Encoded Proteins
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:12715058-12722371
Strand Forward strand
Band p13.1
Transcripts
ENST00000228872 ENSP00000228872
ENST00000396340 ENSP00000379629
ENST00000442489 ENSP00000407597
ENST00000477087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 157 [view]
Protein-Protein 145 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903 protein phosphatase binding
GO:0030544 Hsp70 protein binding
GO:0032403 protein complex binding
GO:0051087 chaperone binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001666 response to hypoxia
GO:0006813 potassium ion transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 cell cycle arrest
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0008219 cell death
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009749 response to glucose
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0032355 response to estradiol
GO:0033673 negative regulation of kinase activity
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0045087 innate immune response
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0046686 response to cadmium ion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048102 autophagic cell death
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051271 negative regulation of cellular component movement
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236 cellular response to antibiotic
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
GO:0071850 mitotic cell cycle arrest
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
Oncostatin_M pathway
REACTOME
DNA Replication pathway
Signaling by FGFR in disease pathway
p53-Dependent G1/S DNA damage checkpoint pathway
G1 Phase pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Synthesis of DNA pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Mitotic G1-G1/S phases pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
S Phase pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Cyclin D associated events in G1 pathway
Fc epsilon receptor (FCERI) signaling pathway
G1/S Transition pathway
Signal Transduction pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Removal of licensing factors from origins pathway
Immune System pathway
Downstream signal transduction pathway
p53-Dependent G1 DNA Damage Response pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
NGF signalling via TRKA from the plasma membrane pathway
Switching of origins to a post-replicative state pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
G1/S DNA Damage Checkpoints pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Signaling by ERBB2 pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Cell Cycle Checkpoints pathway
KEGG
ErbB signaling pathway pathway
Cell cycle pathway
Pathways in cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Small cell lung cancer pathway
INOH
Hedgehog signaling pathway pathway
PID BIOCARTA
Cell cycle: g1/s check point [Biocarta view]
Cdk regulation of dna replication [Biocarta view]
Ctcf: first multivalent nuclear factor [Biocarta view]
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
Cyclins and cell cycle regulation [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
PID NCI
Class I PI3K signaling events mediated by Akt
Regulation of retinoblastoma protein
Integrins in angiogenesis
Validated targets of C-MYC transcriptional repression
FoxO family signaling
Notch-mediated HES/HEY network
Regulation of RhoA activity
AP-1 transcription factor network
C-MYB transcription factor network
E2F transcription factor network
RhoA signaling pathway
FOXA1 transcription factor network
Regulation of Telomerase
Cross-References
SwissProt P46527
TrEMBL B4DPH2 Q6I9V6 Q9UH60
UniProt Splice Variant
Entrez Gene 1027
UniGene Hs.238990 Hs.593269 Hs.628402
RefSeq NM_004064
HUGO HGNC:1785
OMIM 600778
CCDS CCDS8653
HPRD 02867
IMGT
EMBL AB451291 AB451423 AF213700 AF480891 AK298335 AK312461 BC001971 BT019553 BT019554 CH471094 CR457399 S76986 S76988 U10906
GenPept AAA20240 AAD14244 AAF21058 AAH01971 AAL78041 AAV38360 AAV38361 BAG35368 BAG60584 BAG70105 BAG70237 CAG33680 EAW96275
RNA Seq Atlas 1027