Version 5.4
Mus musculus Gene: Sema6d
Summary
InnateDB Gene IDBG-203251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema6d
Gene Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027200
Encoded Proteins
IDBP-203253
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203255
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203257
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203259
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203261
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203263
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203265
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
IDBP-203267
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137872:
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:124089969-124667770
Strand Forward strand
Band F1
Transcripts
ENSMUST00000103241 ENSMUSP00000099531
ENSMUST00000051419 ENSMUSP00000061123
ENSMUST00000103240 ENSMUSP00000099530
ENSMUST00000103239 ENSMUSP00000099529
ENSMUST00000076335 ENSMUSP00000075674
ENSMUST00000077847 ENSMUSP00000077014
ENSMUST00000078621 ENSMUSP00000077691
ENSMUST00000103238 ENSMUSP00000099528
ENSMUST00000137172
ENSMUST00000151199
ENSMUST00000132088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0007275 multicellular organismal development
GO:0014911 positive regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0021591 ventricular system development
GO:0030154 cell differentiation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137872
View Gene Order
ENSBTAG00000016800
Not yet available
Pathways
NETPATH
REACTOME
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_231928
Other semaphorin interactions pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q76KF0
TrEMBL
UniProt Splice Variant
Entrez Gene 214968
UniGene Mm.330536 Mm.412083 Mm.473513
RefSeq NM_001290997 NM_001291000 NM_172537 NM_199238 NM_199239 NM_199240 NM_199241 XM_006499116 XM_006499117
OMIM
CCDS CCDS16672 CCDS16670 CCDS16671 CCDS16673 CCDS38225 CCDS71132
HPRD
IMGT
MGI ID MGI:2387661
MGI Symbol Sema6d
EMBL AB091532 AB091533 AB091534 AB091535 AB091536 AK122515 AL935323 BC060680
GenPept AAH60680 BAC65797 BAD05168 BAD05169 BAD05170 BAD05171 BAD05172 CAM20227
RNA Seq Atlas 214968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca