Mus musculus Gene: Sema6d
Summary
InnateDB Gene IDBG-203251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema6d
Gene Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027200
Encoded Proteins
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137872:
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:124089969-124667770
Strand Forward strand
Band F1
Transcripts
ENSMUST00000103241 ENSMUSP00000099531
ENSMUST00000051419 ENSMUSP00000061123
ENSMUST00000103240 ENSMUSP00000099530
ENSMUST00000103239 ENSMUSP00000099529
ENSMUST00000076335 ENSMUSP00000075674
ENSMUST00000077847 ENSMUSP00000077014
ENSMUST00000078621 ENSMUSP00000077691
ENSMUST00000103238 ENSMUSP00000099528
ENSMUST00000137172
ENSMUST00000151199
ENSMUST00000132088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0007275 multicellular organismal development
GO:0014911 positive regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0021591 ventricular system development
GO:0030154 cell differentiation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
Axon guidance pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.330536 Mm.412083 Mm.473513
RefSeq NM_001290997 NM_001291000 NM_172537 NM_199238 NM_199239 NM_199240 NM_199241 XM_006499116 XM_006499117
OMIM
CCDS CCDS16670 CCDS16671 CCDS16672 CCDS16673 CCDS38225 CCDS71132
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas