Homo sapiens Gene: ITGA2
Summary
InnateDB Gene IDBG-20326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA2
Gene Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Synonyms BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2;
Species Homo sapiens
Ensembl Gene ENSG00000164171
Encoded Proteins
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:52989326-53094779
Strand Forward strand
Band q11.2
Transcripts
ENST00000296585 ENSP00000296585
ENST00000503810 ENSP00000426489
ENST00000513685 ENSP00000422095
ENST00000509960 ENSP00000424642
ENST00000509814 ENSP00000424397
ENST00000510722 ENSP00000422145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0032403 protein complex binding
GO:0038064 collagen receptor activity
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0002687 positive regulation of leukocyte migration
GO:0006928 cellular component movement
GO:0006929 substrate-dependent cell migration
GO:0006971 hypotonic response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0009887 organ morphogenesis
GO:0010634 positive regulation of epithelial cell migration
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0014850 response to muscle activity
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016032 viral process
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0031346 positive regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0032870 cellular response to hormone stimulus
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033343 positive regulation of collagen binding
GO:0033591 response to L-ascorbic acid
GO:0033627 cell adhesion mediated by integrin
GO:0038065 collagen-activated signaling pathway
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043388 positive regulation of DNA binding
GO:0043589 skin morphogenesis
GO:0045184 establishment of protein localization
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045987 positive regulation of smooth muscle contraction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050927 positive regulation of positive chemotaxis
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070365 hepatocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009279 cell outer membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0042995 cell projection
GO:0043679 axon terminus
GO:0045178 basal part of cell
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Extracellular matrix organization pathway
CHL1 interactions pathway
Syndecan interactions pathway
Axon guidance pathway
Platelet Adhesion to exposed collagen pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
L1CAM interactions pathway
Laminin interactions pathway
Hemostasis pathway
KEGG
Phagosome pathway
Focal adhesion pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Syndecan-2-mediated signaling events
Beta1 integrin cell surface interactions
Integrin family cell surface interactions
VEGFR3 signaling in lymphatic endothelium
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002203
HUGO
OMIM
CCDS CCDS3957
HPRD 01893
IMGT
EMBL
GenPept
RNA Seq Atlas