InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mgst3

Summary

InnateDB Gene

IDBG-203280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgst3

Gene Name

microsomal glutathione S-transferase 3

Synonyms

2010012L10Rik; 2010306B17Rik; 2700004G04Rik; AA516734; GST-III

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026688

Encoded Proteins

IDBP-203282

microsomal glutathione S-transferase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143198:
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:167371966-167393841

Strand

Reverse strand

Band

H2.3

Transcripts

ENSMUST00000028005

ENSMUSP00000028005

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity

Biological Process

GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome