InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLK1

Summary

InnateDB Gene

IDBG-20347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLK1

Gene Name

delta-like 1 homolog (Drosophila)

Synonyms

Delta1; DLK; DLK-1; FA1; pG2; Pref-1; PREF1; ZOG

Species

Homo sapiens

Ensembl Gene

ENSG00000185559

Encoded Proteins

IDBP-20349

delta-like 1 homolog (Drosophila)

IDBP-20351

delta-like 1 homolog (Drosophila)

IDBP-244765

delta-like 1 homolog (Drosophila)

IDBP-599289

delta-like 1 homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22072963

DLK1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. DLK1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22072963

[Mus musculus] Dlk1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. Dlk1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection.

Entrez Gene

Summary

This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:100725705-100738224

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000331224	ENSP00000331081
ENST00000341267	ENSP00000340292
ENST00000392848	ENSP00000376589
ENST00000555747
ENST00000556051	ENSP00000450821

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development