Homo sapiens Gene: REST
Summary
InnateDB Gene IDBG-20380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REST
Gene Name RE1-silencing transcription factor
Synonyms NRSF; XBR;
Species Homo sapiens
Ensembl Gene ENSG00000084093
Encoded Proteins
RE1-silencing transcription factor
RE1-silencing transcription factor
RE1-silencing transcription factor
RE1-silencing transcription factor
RE1-silencing transcription factor
RE1-silencing transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RE-1 silencing transcription factor (REST) is part of a repressor complex, along with key components that include histone deacetylase (HDAC) 1 or 2, co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.
Entrez Gene
Summary This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:56907876-56935844
Strand Forward strand
Band q12
Transcripts
ENST00000309042 ENSP00000311816
ENST00000511065
ENST00000503522
ENST00000514063
ENST00000619101 ENSP00000484836
ENST00000622863 ENSP00000481650
ENST00000612429 ENSP00000484206
ENST00000611211 ENSP00000479151
ENST00000616975 ENSP00000484058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 56 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0015271 outward rectifier potassium channel activity
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010629 negative regulation of gene expression
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0035690 cellular response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0045087 innate immune response (InnateDB)
GO:0045665 negative regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0050768 negative regulation of neurogenesis
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0070933 histone H4 deacetylation
GO:0071257 cellular response to electrical stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071805 potassium ion transmembrane transport
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000706 negative regulation of dense core granule biogenesis
GO:2000740 negative regulation of mesenchymal stem cell differentiation
GO:2000798 negative regulation of amniotic stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001193508 NM_005612 XM_005265760
HUGO
OMIM
CCDS CCDS3509
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas