InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: REST

Summary

InnateDB Gene

IDBG-20380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REST

Gene Name

RE1-silencing transcription factor

Synonyms

NRSF; XBR

Species

Homo sapiens

Ensembl Gene

ENSG00000084093

Encoded Proteins

IDBP-20384

RE1-silencing transcription factor

IDBP-807188

RE1-silencing transcription factor

IDBP-807201

RE1-silencing transcription factor

IDBP-807202

RE1-silencing transcription factor

IDBP-807204

RE1-silencing transcription factor

IDBP-807205

RE1-silencing transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20798038

RE-1 silencing transcription factor (REST) is part of a repressor complex, along with key components that include histone deacetylase (HDAC) 1 or 2, co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:56907876-56935844

Strand

Forward strand

Band

q12

Transcripts

ENST00000309042	ENSP00000311816
ENST00000511065
ENST00000503522
ENST00000514063
ENST00000619101	ENSP00000484836
ENST00000622863	ENSP00000481650
ENST00000612429	ENSP00000484206
ENST00000611211	ENSP00000479151
ENST00000616975	ENSP00000484058

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	56 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015271	outward rectifier potassium channel activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0035690	cellular response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922	negative regulation by host of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050768	negative regulation of neurogenesis
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0070933	histone H4 deacetylation
GO:0071257	cellular response to electrical stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071805	potassium ion transmembrane transport
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000706	negative regulation of dense core granule biogenesis
GO:2000740	negative regulation of mesenchymal stem cell differentiation
GO:2000798	negative regulation of amniotic stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0017053	transcriptional repressor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029249

View Gene Order

ENSBTAG00000011789

Not yet available

Pathways

NETPATH

REACTOME

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.307836 Hs.633323

RefSeq

NM_001193508 NM_005612 XM_005265760

HUGO

OMIM

CCDS

CCDS3509

HPRD

08990

IMGT

EMBL

GenPept

RNA Seq Atlas