Version 5.4
Mus musculus Gene: Mfn2
Summary
InnateDB Gene IDBG-203813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfn2
Gene Name mitofusin 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029020
Encoded Proteins
IDBP-203815
mitofusin 2
IDBP-270290
mitofusin 2
IDBP-270292
mitofusin 2
IDBP-270294
mitofusin 2
IDBP-535947
mitofusin 2
IDBP-541312
mitofusin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21285412
Mfn2 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and proinflammatory cytokines in response to viral infection - which results in increased viral replication.
PMID 24127597
Mitochondrial membrane potential is required for the association of Nlrp3 and Mfn2. Mfns2 is required for the activation of Nlrp3 inflammasomes.
InnateDB Annotation from Orthologs
Summary
PMID 21285412
[Homo sapiens] MFN2 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116688:
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:147873599-147904704
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000030884 ENSMUSP00000030884
ENSMUST00000105716 ENSMUSP00000101341
ENSMUST00000105715 ENSMUSP00000101340
ENSMUST00000105714 ENSMUSP00000101339
ENSMUST00000124646
ENSMUST00000134172 ENSMUSP00000123021
ENSMUST00000150881 ENSMUSP00000117758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001825 blastocyst formation
GO:0006184 GTP catabolic process
GO:0006626 protein targeting to mitochondrion
GO:0007006 mitochondrial membrane organization
GO:0008053 mitochondrial fusion
GO:0045087 innate immune response (InnateDB)
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048593 camera-type eye morphogenesis
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051646 mitochondrion localization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
GO:0031306 intrinsic to mitochondrial outer membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116688
View Gene Order
ENSBTAG00000005314
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.437499 Mm.488699
RefSeq NM_001285920 NM_001285921 NM_001285922 NM_001285923 NM_133201 XM_006535925 XM_006538609 XM_006538610 XM_006538611
OMIM
CCDS CCDS38965
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca