InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf135

Summary

InnateDB Gene

IDBG-204021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf135

Gene Name

ring finger protein 135

Synonyms

0610037N03Rik; 2410006N06Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020707

Encoded Proteins

IDBP-204023

ring finger protein 135

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23950712

[Homo sapiens] RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181481:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:80183851-80199757

Strand

Forward strand

Band

Transcripts

ENSMUST00000017839	ENSMUSP00000017839
ENSMUST00000134909

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response