Version 5.4
Mus musculus Gene: Fcgr4
Summary
InnateDB Gene IDBG-204029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcgr4
Gene Name Fc receptor, IgG, low affinity IV
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000059089
Encoded Proteins
IDBP-204031
Fc receptor, IgG, low affinity IV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203747:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171018920-171029761
Strand Forward strand
Band H3
Transcripts
ENSMUST00000078825 ENSMUSP00000077873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000203747
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05150
Staphylococcus aureus infection pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_21
RANKL pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05322
Systemic lupus erythematosus pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 246256
UniGene Mm.251254
RefSeq NM_144559
OMIM
CCDS CCDS15476
HPRD
IMGT
MGI ID MGI:2179523
MGI Symbol Fcgr4
EMBL
GenPept
RNA Seq Atlas 246256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca