InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hspb1

Summary

InnateDB Gene

IDBG-204151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspb1

Gene Name

heat shock protein 1

Synonyms

27kDa; Hsp25

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004951

Encoded Proteins

IDBP-204153

heat shock protein 1

IDBP-258724

heat shock protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106211:
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135887919-135889563

Strand

Forward strand

Band

Transcripts

ENSMUST00000005077	ENSMUSP00000005077
ENSMUST00000111155	ENSMUSP00000106785

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001895	retina homeostasis
GO:0006469	negative regulation of protein kinase activity
GO:0006986	response to unfolded protein
GO:0009615	response to virus
GO:0032731	positive regulation of interleukin-1 beta production
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028	positive regulation of endothelial cell chemotaxis
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0030018	Z disc
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome