InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usf1

Summary

InnateDB Gene

IDBG-204574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usf1

Gene Name

upstream transcription factor 1

Synonyms

bHLHb11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026641

Encoded Proteins

IDBP-204576

upstream transcription factor 1

IDBP-534896

upstream transcription factor 1

IDBP-539193

upstream transcription factor 1

IDBP-539022

upstream transcription factor 1

IDBP-622523

upstream transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158773:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:171411313-171420352

Strand

Forward strand

Band

Transcripts

ENSMUST00000001284	ENSMUSP00000001284
ENSMUST00000161241	ENSMUSP00000125729
ENSMUST00000159207	ENSMUSP00000124000
ENSMUST00000161297
ENSMUST00000160335
ENSMUST00000159466
ENSMUST00000160486	ENSMUSP00000125363
ENSMUST00000159929
ENSMUST00000159371
ENSMUST00000167546	ENSMUSP00000128913

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	6 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0001666	response to hypoxia
GO:0006006	glucose metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008150	biological_process
GO:0009411	response to UV
GO:0019086	late viral transcription
GO:0032869	cellular response to insulin stimulus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055088	lipid homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005739	mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158773

View Gene Order

ENSBTAG00000017873

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.410390 Mm.8

RefSeq

NM_001164525 NM_009480 XM_006496747

OMIM

CCDS

CCDS15495 CCDS48443

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas