Version 5.4
Mus musculus Gene: Cckbr
Summary
InnateDB Gene IDBG-204676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cckbr
Gene Name cholecystokinin B receptor
Synonyms CCK2R; CCKR-2
Species Mus musculus
Ensembl Gene ENSMUSG00000030898
Encoded Proteins
IDBP-204680
cholecystokinin B receptor
IDBP-722234
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110148:
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:105425817-105470898
Strand Forward strand
Band E3
Transcripts
ENSMUST00000033189 ENSMUSP00000033189
ENSMUST00000181339 ENSMUSP00000138052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015054 gastrin receptor activity
GO:0031741 type B gastrin/cholecystokinin receptor binding
Biological Process
GO:0001696 gastric acid secretion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110148
View Gene Order
ENSBTAG00000005236
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8BYG7
UniProt Splice Variant
Entrez Gene 12426
UniGene Mm.406815 Mm.44513
RefSeq NM_007627 XM_006507280 XM_006507281
OMIM
CCDS CCDS21651
HPRD
IMGT
MGI ID MGI:99479
MGI Symbol Cckbr
EMBL AC125055 AK039721
GenPept BAC30428
RNA Seq Atlas 12426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca