Mus musculus Gene: Serpine1
Summary
InnateDB Gene IDBG-204786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpine1
Gene Name serine (or cysteine) peptidase inhibitor, clade E, member 1
Synonyms PAI-1; PAI1; Planh1;
Species Mus musculus
Ensembl Gene ENSMUSG00000037411
Encoded Proteins
serine (or cysteine) peptidase inhibitor, clade E, member 1
serine (or cysteine) peptidase inhibitor, clade E, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Serpine1 is a critical mediator that controls the development of the early lung inflammation induced by Pseudomonas aeruginosa infections.
Serpine1 plays a critical role in early host defense response against Haemophilus influenzae infection. Serpine1 knockout mice show reduced bacterial clearance and prolonged pneumonia.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SERPINE1 is a critical mediator of the pulmonary host response that controls the development of the early lung inflammation induced by Pseudomonas aeruginosa infections. (Demonstrated in mouse)
[Homo sapiens] SERPINE1 plays a critical role in early host defense response against Haemophilus influenzae infection. Serpine1 knockout mice show reduced bacterial clearance and prolonged pneumonia. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106366:
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137061504-137072272
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000041388 ENSMUSP00000039586
ENSMUST00000077523 ENSMUSP00000076728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001300 chronological cell aging
GO:0001525 angiogenesis
GO:0010469 regulation of receptor activity
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0030194 positive regulation of blood coagulation
GO:0030336 negative regulation of cell migration
GO:0032757 positive regulation of interleukin-8 production
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035491 positive regulation of leukotriene production involved in inflammatory response
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051918 negative regulation of fibrinolysis
GO:0061044 negative regulation of vascular wound healing
GO:0071222 cellular response to lipopolysaccharide
GO:0090026 positive regulation of monocyte chemotaxis
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
Complement and coagulation cascades pathway
Chagas disease (American trypanosomiasis) pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Prolactin pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Circadian Clock pathway
Dissolution of Fibrin Clot pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Extracellular matrix organization pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
ECM proteoglycans pathway
Response to elevated platelet cytosolic Ca2+ pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
Platelet degranulation pathway
Extracellular matrix organization pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
ECM proteoglycans pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Dissolution of Fibrin Clot pathway
Circadian Clock pathway
KEGG
p53 signaling pathway pathway
Complement and coagulation cascades pathway
Chagas disease (American trypanosomiasis) pathway
INOH
PID BIOCARTA
Fibrinolysis pathway [Biocarta view]
Platelet amyloid precursor protein pathway [Biocarta view]
PID NCI
Direct p53 effectors
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
HIF-2-alpha transcription factor network
p73 transcription factor network
E2F transcription factor network
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL D0ESZ5 G5E899
UniProt Splice Variant
Entrez Gene 18787
UniGene Mm.250422
RefSeq NM_008871
OMIM
CCDS CCDS19761
HPRD
IMGT
MGI ID MGI:97608
MGI Symbol Serpine1
EMBL AC147986 CH466529 GQ872458
GenPept ACX48997 EDL19287
RNA Seq Atlas 18787