InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ilk

Summary

InnateDB Gene

IDBG-204955.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ilk

Gene Name

integrin linked kinase

Synonyms

AA511515; ESTM24

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030890

Encoded Proteins

IDBP-204957

integrin linked kinase

IDBP-531763

integrin linked kinase

IDBP-541924

integrin linked kinase

IDBP-627761

integrin linked kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166333:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:105736592-105742925

Strand

Forward strand

Band

Transcripts

ENSMUST00000033182	ENSMUSP00000033182
ENSMUST00000149695
ENSMUST00000136687	ENSMUSP00000123443
ENSMUST00000145123
ENSMUST00000154626
ENSMUST00000148971
ENSMUST00000153557
ENSMUST00000127298	ENSMUSP00000116329
ENSMUST00000151108
ENSMUST00000152508
ENSMUST00000130565
ENSMUST00000138150
ENSMUST00000163389	ENSMUSP00000130341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007229	integrin-mediated signaling pathway
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010761	fibroblast migration
GO:0014044	Schwann cell development
GO:0014912	negative regulation of smooth muscle cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0021675	nerve development
GO:0022011	myelination in peripheral nervous system
GO:0030030	cell projection organization
GO:0030335	positive regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032288	myelin assembly
GO:0032956	regulation of actin cytoskeleton organization
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043206	extracellular fibril organization
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663	positive regulation of myoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045773	positive regulation of axon extension
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048812	neuron projection morphogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051291	protein heterooligomerization
GO:0051897	positive regulation of protein kinase B signaling
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030017	sarcomere
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043034	costamere
GO:0043195	terminal bouton
GO:0043198	dendritic shaft
GO:0043234	protein complex