InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ephb4

Summary

InnateDB Gene

IDBG-204963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb4

Gene Name

Eph receptor B4

Synonyms

AI042935; Htk; MDK2; Myk1; Tyro11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029710

Encoded Proteins

IDBP-204965

Eph receptor B4

IDBP-258917

Eph receptor B4

IDBP-258919

Eph receptor B4

IDBP-539518

Eph receptor B4

IDBP-620781

Eph receptor B4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196411:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:137350109-137378669

Strand

Forward strand

Band

Transcripts

ENSMUST00000061244	ENSMUSP00000051622
ENSMUST00000111055	ENSMUSP00000106684
ENSMUST00000111054	ENSMUSP00000106683
ENSMUST00000144296	ENSMUSP00000115731
ENSMUST00000166239	ENSMUSP00000130275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0003007	heart morphogenesis
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway